We examine the dynamic interaction between the growing actin network with the cell membrane using a 3-dimensional computational model. The roles of actin-associated proteins in generating the flat lamellipodium are explored. We show that the distinct pattern formed in the lamellipodium suggests an unique Arp2/3 branching mechanism.
The mechanics of the plasma membrane and its effect on the growing lamellipodium and filopodium are discussed. Computations suggest that membrane fluctuations enhance the actin growth and protrusion speed.
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