Ventricular remodeling of both geometry and fiber structure is a prominent feature of several cardiac pathologies. Advances in magnetic resonance imaging and analytical methods now make it possible to measure changes of cardiac geometry, fiber and sheet orientation at high spatial resolution. We present diffusion tensor imaging techniques to measure the geometry and fiber architecture of canine hearts. We also present computational methods, specifically the Large Deformation Metric Mapping method, to identify statistically significant changes of cardiac anatomic structure in failing and control heart populations. Finally, we will show recently published results quantifying the structural remodeling that occurs in the dyssynchronous failing heart.
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