UCLA/Orthopedic Hospital Department of Orthopedic Surgery and UCLA's Institute of Pure and Applied Mathematics announce The first workshop on Bone Tissue: Hierarchical Simulations for Clinical Applications (BTHSCA1) April 21-23, 2010 at UCLA Endorsed by Call for Abstracts

BTHSCA1 aims to bring together orthopedic surgeons, clinicians, system biologists, mechanical and software engineers, and applied mathematicians to share the latest findings and formulate a plan to develop the next generation of three-dimensional multi-scale virtual rendering of bone tissue able to address specific clinical issues. The need for this workshop is based on

• the increasing evidence that bone shows a plethora of divergent characteristics through a hierarchically-organized heterogeneous structure that varies across nano- micro- , and macro- length scales; and
• the highly interdisciplinary nature of hierarchical modeling, based on developments that occur independently across multiple scientific disciplines and address phenomena manifested at the different scales.

Workshop topics will include:

• Effect of bone pathology on macro and/or micro- and/or nano-scale structure
• Multiscale approaches to clinical issues
• Clinical alterations of micro- and/or nano- scale structure
• Multiscale parameters of bone tissue quality
• Scale transition in bone simulation
• Fracture prediction in multiscale systems
• Data collection at nano-, micro-, or macro- level for bone simulation
• Management of large data sets
• Pattern recognition and/or data mining in collected data
• Biological variation of data in statistical terms: What does "normal" mean?
• Experimental design for specific modeling purposes
• The mathematics of the interaction of bone tissue's components
• Adherence of modeling to experimental findings
• Software design for implementation of engineering simulation
• Interactions between non-biological materials and bone tissue
• Super-computing resources for complex modeling

Organizing Committee

Maria-Grazia Ascenzi, PhD in Mathematics
UCLA/Orthopedic Hospital Department of Orthopedic Surgery
Research interests: Bone micro-mechanics, mathematical modeling
mgascenzi@mednet.ucla.edu

John S. Adams, MD
UCLA/Orthopedic Hospital Department of Orthopedic Surgery
Research interests: Molecular motive action of vitamin D in human bone

Elena Cherkaev, PhD in Mathematics
Department of Mathematics, University of Utah
Research interests: Inverse problems, optimization, simulation of heterogeneous materials and biological tissues

Paul C. Dechow, PhD in Anatomy
Professor of Biomedical Sciences, Texas A&M Baylor College of Dentistry
Research interests: Hard tissue microstructure and material properties; growth, adaptation, and evolution of the craniofacial skeleton

Eve Donnelly, PhD in Mechanical Engineering
Mineralized Tissues Laboratory, Hospital for Special Surgery
Research interests: Contribution of bone mineral and matrix properties to material and structural behavior

Gwendolen Reilly, PhD in Biology
Engineering Materials, University of Sheffield, United Kingdom
Research interests: Mechanical stimulation in bone tissue engineering

Keynote Speakers

David Burr, Professor, Department of Anatomy and Cell Biology and Department of Orthopedic Surgery Indiana University School of Medicine, Department of Biomedical Engineering IUPUI and Purdue University
Research Interests: Effects of pharmacologic treatments of osteoporosis; microdamage; quality of bone matrix
www.anatomy.iupui.edu

Marjolein van der Meulen, Professor of Mechanical and Aerospace Engineering, Cornell University
Research Interests: bone tissue mechanics; determinants of skeletal mechanical behavior; bone adaptation to mechanical stimuli
www.mae.cornell.edu/index.cfm/page/fac/vanderMeulen.htm

Nico Verdonschot, Professor of Orthopedic Surgery and Traumatology, Radboud University, The Netherlands Research Interests: Frictional, morphological and material properties of the cement-bone interface; finite element methods
www.umcn.nl/scientist

Residents and junior investigators, and women, underrepresented minorities and individuals with disabilities are encouraged to apply: scholarships will be awarded to the first author of the nine most meritorious abstracts.

Registration Fees

Early registration (by March 15, 2010): full $100; residents and junior investigators $50; students $25
On site registration: full $150; residents and junior investigators $75; students $40

Abstract Requirements

Length: one page containing one image
Margins: 0.5in
Font: Arial 11pt
Content: Title, authors with institutions, introduction, methods, results, references (optional), at least one workshop topic, contact information of first author including email address, whether a resident, junior investigator (within five years from a PhD), woman, underrepresented minority, person with disability.

Important Deadlines

Submit abstract here. Register here.  Please pay your registration fee when you register.  Registration after January 15, please pay your fee in person on the first day of the conference.

Suggested Hotels

Please consult IPAM's hotel page to find a local hotel for your visit. UCLA Guest House, Tiverton House, and Hilgard House are recommended.

Reception

On Thursday night, UCLA’s Institute of Pure and Applied Mathematics (IPAM) will sponsor a reception on campus.